Research

I do research in three fields: Space Medicine, Sport Medicine and Orthopaedic Surgery. Several students are involved in the projects and I work with many international collaborators.

My main field of research is the musculoskeletal system in spaceflight. The human body adapts to weightlessness, and space flight participants experience bone and muscle loss, back pain, cardiovascular deconditioning, and a lot more. I work on bone loss and bone adaptation, changes of skeletal muscle tissue in unloading and microgravity as well as on space flight back pain and the question what exactly happens while astronauts grow by about 5 cm in weightlessness. Most of the research is conducted in bedrest-studies together with DLR (Jörn Rittweger), ESA and NASA.

In Addition, I am interested in master athletics, performance declines with age and age-related adaptations of the human body to sports. To collect data, we do field studies at competitions, such as at international master athletics championships (track and field) and the Master British Open (Tennis). My main collaborator here is Hans Degens of Manchester Metropolitan University.

Furthermore, I am running a number of surgical research-projects with Matthias Knobe that deal with injury, wound healing, microcirculation and inflammation. The team in Aachen mainly uses the O2C (Oxygen To See) device to study microcirculation after injury and surgery.

See the recordings of two conference talks I gave in London and Prague here!

Most of my research papers are listed here in Pubmed, and this is my Researchgate profile. My ORCID-ID is 0000-0002-9512-2910. This is a list of my published research articles in peer-reviewed journals:

2018:

  1. Opatz O, Nordine N, Habazettl H, Ganse B, Petricek J, Dosel P, Stahn A, Steinach M, Gunga HC, Maggioni MA. Hot Legs Make Me Faint: Limb Skin Temperature as a Tool to Predict Orthostatic Instability. Front Physiol. [accepted]
  2. Ganse B, Degens H. Accelerated decline in javelin throwing performance in master athletes 70 years and older. Sports Med Int Open. [accepted]
  3. Debevec T, Ganse B, Mittag U, Eiken O, Mekjavic IB, Rittweger J. Hypoxia Aggravates Inactivity-related Muscle Wasting. Front Physiol. 15 May 2018, doi: 10.3389/fphys.2018.00494

2017:

  1. Ganse B, Pishnamaz M, Kobbe P, Herren C, Gradl-Dietsch G, Böhle F, Johannes B, Kim BS, Horst K, Knobe M. Microcirculation in open vs. minimally invasive dorsal stabilization of thoracolumbar fractures. PLOS ONE 12(11):e0188115.
  2. Kösters AK, Ganse B, Gueorguiev B, Klos K, Modabber A, Nebelung S, Kim BS, Knobe M. Effects of low-intensity pulsed ultrasound on soft tissue micro-circulation in the foot. Int Orthop. 2017 Oct;41(10):2067-2074.
  3. Koy T*, Ganse B*, Zange J, Rittweger J, Pohle-Fröhlich R, Frings-Meuthen P, Johannes B, Felsenberg D, Eysel P, Bansmann PM, Belavy DL. T2-relaxation time increases in lumbar intervertebral discs after 21 d head-down tilt bed-rest. J Musculoskelet Neuronal Interact. 2017 Sep 1;17(3):140-145. * shared first-authorship
  4. Kim BS, Tilstam PV, Springenberg-Jung K, Boecker AH, Schmitz C, Heinrichs D, Hwang SS, Stromps JP, Ganse B, Kopp R, Knobe M, Bernhagen J, Pallua N, Bucala R. Characterization of adipose tissue macrophages and adipose-derived stem cells in critical wounds. PeerJ. 2017 Jan;5:e2824
  5. Kim BS, Tilstam PV, Hwang SS, Simons D, Schulte W, Leng L, Sauler M, Ganse B, Averdunk L, Kopp R, Stoppe C, Bernhagen J, Pallua N, Bucala R. D-dopachrome tautomerase in adipose tissue inflammation and wound repair. J Cell Mol Med. 2017 Jan;21(1):35-45.

2016:

  1. Drey M, Sieber CC, Degens H, McPhee J, Korhonen MT, Müller K, Ganse B, Rittweger J. Relation between muscle mass, motor units and type of training in master athletes. Clin Physiol Funct Imaging. 2016 Jan;36(1):70-6.
  2. Ganse B, Yang PF, Gardlo J, Gauger P, Kriechbaumer A, Pape HC, Koy T, Müller LP, Rittweger J. Partial weight bearing of the tibia. Injury. 2016 Aug;47(8):1777-82
  3. Bosutti A, Salanova M, Blottner D, Buehlmeier J, Mulder E, Rittweger J, Yap MH, Ganse B, Degens H. Whey protein with potassium bicarbonate supplement attenuates the reduction in muscle oxidative capacity during 19 days bed rest. J Appl Physiol (1985). 2016 Oct 1;121(4):838-848.
  4. Rittweger J, Debevec T, Frings-Meuthen P, Lau P, Mittag U, Ganse B, Ferstl PG, Simpson EJ, Macdonald IA, Eiken O, Mekjavic IB. On the combined effects of normobaric hypoxia and bed rest upon bone and mineral metabolism: Results from the PlanHab study. Bone. 2016 Oct;91:130-8
  5. Pastor T, Gradl G, Klos K, Ganse B, Horst K, Andruszkow H, Hildebrand F, Pape HC, Knobe M. Displaced intra-articular calcaneal fractures: is there a consensus on treatment in Germany? Int Orthop. 2016 Oct;40(10):2181-2190.
  6. Gradl-Dietsch G, Korden T, Modabber A, Sönmez TT, Stromps JP, Ganse B, Pape HC, Knobe M. Multidimensional approach to teaching anatomy – Do gender and learning style matter? Ann Anat. 2016 Nov;208:158-164.

2015:

  1. Yang PF, Kriechbaumer A, Albracht K, Sanno M, Ganse B, Koy T, Shang P, Brüggemann GP, Müller LP, Rittweger J. On the relationship between tibia torsional deformation and regional muscle contractions in habitual human exercises in vivo. J Biomech. 2015 Feb 5;48(3):456-64
  2. Ganse B, Zange J, Weber T, Pohle-Fröhlich R, Johannes B, Hackenbroch M, Rittweger J, Eysel P, Koy T. Muscular forces affect the glycosaminoglycan content of joint cartilage. Acta Orthop. 2015 Jun;86(3):388-92
  3. Ireland A, Degens H, Ganse B, Maden-Wilkinson TM, Wilks DC, Rittweger J. Greater tibial bone strength in male tennis players than controls in the absence of greater muscle output. Journal of Orthopaedic Translation. 2015 July 3(3):142-51
  4. Drey M, Sieber CC, Degens H, Mc Phee J, Korhonen MT, Ganse B, Müller K, Rittweger J. Successful ageing: Muscle Atrophy and Motor Neuronal Loss in Everyday Athletes. Zeitschrift für Gerontologie + Geriatrie. 2015 Sept 48:27-27
  5. Bosutti A, Egginton S, Barnouin Y, Ganse B, Rittweger J, Degens H. Local capillary supply in muscle is not determined by local oxidative capacity. J Exp Biol. 2015 Nov;218(Pt 21):3377-80.

2014:

  1. Blottner D, Bosutti A, Degens H, Schiffl G, Gutsmann M, Buehlmeier J, Rittweger J, Ganse B, Heer M, Salanova M. Whey protein plus bicarbonate supplement has little effects on structural atrophy and proteolysis marker immunopatterns in skeletal muscle disuse during 21 days of bed rest. J Musculoskelet Neuronal Interact. 2014 Dec;14(4):432-44
  2. Koy T, Zange J, Rittweger J, Pohle-Fröhlich R, Hackenbroch M, Eysel P, Ganse B. Assessment of Lumbar Intervertebral Disc Glycosaminoglycan Content by Gadolinium-Enhanced MRI before and after 21-Days of Head-Down-Tilt Bedrest. PLOS ONE. 2014 Nov 7;9(11):e112104. doi: 10.1371/journal.pone.0112104
  3. Yang PF, Sanno M, Ganse B, Koy T, Brüggemann GP, Müller LP, Rittweger J. In vivo application of an optical segment tracking approach for bone loading regimes recording in humans: a reliability study. Med Eng Phys. 2014 Aug;36(8):1041-6.
  4. Ganse B, Yang PF, Brüggemann GP, Müller LP, Rittweger J, Koy T. Reply to the letter to the editor by Liu and Li. J Musculoskelet Neuronal Interact. 2014 Jun;14(2):245
  5. Ganse B, Degens H, Drey M, Korhonen M, McPhee J, Mueller K, Johannes B, Rittweger J. Impact of age, performance and athletic event on injury rates in master athletics – first results from an ongoing prospective study. J Muskuloskelet Neuronal Interact. 2014 Jun;14(2):148-54
  6. Yang PF, Sanno M, Ganse B, Koy T, Brüggemann GP, Müller L, Rittweger J. Torsion and antero-posterior bending in the in-vivo human tibia loading regimes during walking and running. PLOS ONE. 2014 Apr 14;9(4):e94525. doi: 10.1371/journal.pone.0094525
  7. Ganse B, Yang PF, Brüggemann GP, Mueller L, Rittweger J, Koy T. In-vivo measurements of human bone deformation using Optical Segment Tracking: surgical approach and validation in a three-point bending test. J Musculoskelet Neuronal Interact. 2014 14(1):95-103
  8. Ireland A, Maden-Wilkinson T, Ganse B, Degens H, Rittweger J. Effects of Age and Starting Age upon Side-Asymmetry in the Arms of Veteran Tennis Players: a Cross-Sectional Study. Osteoporosis int. 2014 25(4):1389-400

Earlier:

  1. Ganse B, Limper U, Bühlmeier J, Rittweger J. Petechiae – reproducible pattern of distribution and increased appearance after bedrest. Aviat Space Environ Med. 2013 84(8):864-6
  2. Ganse B, Behrens P, Benthien JP. Two-stage hip revision arthroplasty: The role of the excision arthroplasty. Eur J Orthop Surg Traumatol. 2008 18:223–228
  3. Ganse B, Bos I, Benthien JP. Ergebnisse der zweizeitigen septischen Hüfttotalendoprothesenrevision an der Klinik für Orthopädie des Universitätsklinikums Schleswig-Holstein, Campus Lübeck. FOCUS MUL, 23(3): 155-160 (2006)
  4. Ganse B, Behrens P, Gellissen J, Krüger S, Benthien JP. Localized nodular pigmented villonodular synovitis of the upper ankle joint-diagnosis and treatment. Z Rheumatol. 2006 May;65(3):231-4.